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Scientist - Laboratory of Biomolecular Structure

Job ID 1662 Date posted 03/07/2019

Brookhaven National Laboratory is a multipurpose research institution funded primarily by the U.S. Department of Energy’s Office of Science. Located on the center of Long Island, New York, Brookhaven Lab brings world-class facilities and expertise to the most exciting and important questions in basic and applied science—from the birth of our universe to the sustainable energy technology of tomorrow. We operate cutting-edge large-scale facilities for studies in physics, chemistry, biology, medicine, applied science, and a wide range of advanced technologies. The Laboratory's almost 3,000 scientists, engineers, and support staff are joined each year by more than 4,000 visiting researchers from around the world. Our award-winning history, including seven Nobel Prizes, stretches back to 1947, and we continue to unravel mysteries from the nanoscale to the cosmic scale, and everything in between. Brookhaven is operated and managed by Brookhaven Science Associates, which was founded by the Research Foundation for the State University of New York on behalf of Stony Brook University, and Battelle, a nonprofit applied science and technology organization.

The Laboratory of Biomolecular Structure (LBMS) is a state-of-the-art center for life-science imaging, just coming into operation at Brookhaven National Laboratory. LBMS provides support on single-particle and tomographic cryogenic Transmission Electron Microscopy (TEM) studies ( The mission of LBMS is to accelerate dramatically our understanding of processes underlying Biology. The LBMS benefits from a location close to the world-leading X-ray-imaging and structural biology user facilities at National Synchrotron Light Source II (NSLS‑II).

 We seek PhD-level scientists who will operate our new cryo-TEMs and ancillary equipment, help develop user programs, communicate with scientific and industrial user commu­nities. Working closely with users, they will define optimal experim­en­tal design on sample preparation and automated data collection. They will provide guidance and service in data management and analysis.

Specifically, these scientists will work with the Group Leader  to operate the cryo-TEMs and ancillary equipment, perform routine maintenance and quality checks to ensure optimal oper­ationand keep records for user projects and interactions.  The electron microscopists will provide technical advice to investigators on sample preparation, and data collection. They will train new investigators in the principles and practice of cryogenic electron microscopy

Each successful candidate will be also expected to develop and to learn new technologies that will facilitate sample preparation, and data acquisition and analysis.

Selected candidate will be placed at the appropriate position level dependent upon depth and breadth of relevant knowledge and skills, as well as years of relevant experience.


  • Ph.D. in structural biology or a related field.
  • More than 3 years expertise in operating high-end cryo-TEM instruments such as Titan Krios.
  • Experience in high-resolution cryo-TEM data collection, analysis, structure-solving, and refinement.
  • Cryogenic preparation of biological samples for single-particle or tomography work.
  • Self-motivated.


  • Experience in developing software for all levels of the atomic-resolution cryo-TEM process.
  • Use of FIB/SEM to prepare and image cryogenic samples.
  • Experience in scripting or programming for automation.
  • Experience with fluorescence light microscopy.
  • Ability to communicate effectively and diplomatically.
  • Strong organizational skills and methodical record-keeping.

Additional Information:
Candidates should submit a cover letter, a CV, and contact information of at least referees so that we can request formal letters of recommendation.

The cover letter for a successful applicant would include a narrative telling of experience in operation of automated cryo-TEMs and ancillary equipment for sample preparation, and in teaching and assisting others in this work. It would include evidence of your experience in loading samples, aligning micro­scopes, performing routine maintenance, and trouble-shooting of problems. We would like to hear of your success with the various software suites for data acquisition, and those for image processing, structure solving, and structure refinement. Finally, we would like to hear about your experiences in providing consulting and support to other researchers in employing cryo-TEM technologies for single-particle microscopy and tomography.

At Brookhaven National Laboratory we believe that a comprehensive employee benefits program is an important and meaningful part of the compensation employees receive. Our benefits program includes, but is not limited to:

  • Medical Plans
  • Dental Plans
  • Vacation
  • Holidays
  • Life Insurance
  • 401(k) Plan
  • Retirement Plan
  • Paid Parental Leave
  • Swimming Pool, Weight Room, Tennis Courts, and many other employee perks and benefits

We invite you to consider Brookhaven National Laboratory for employment. To be considered for this position, please apply online at BNL Careers and enter the job title into the Keyword Search.

Brookhaven National Laboratory (BNL) is an equal opportunity employer committed to ensuring that all qualified applicants receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, status as a veteran, disability or any other federal, state or local protected class.

BNL takes affirmative action in support of its policy and to advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.

*VEVRAA Federal Contractor

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Brookhaven employees are subject to restrictions related to participation in Foreign Government Talent Recruitment Programs, as defined and detailed in United States Department of Energy Order 486.1. You will be asked to disclose any such participation at the time of hire for review by Brookhaven. The full text of the Order may be found at:

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