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Postdoctoral Research Associate Structural Biology

Job ID 2535 Date posted 08/31/2021

Brookhaven National Laboratory ( delivers discovery science and transformative technology to power and secure the nation’s future. Brookhaven Lab is a multidisciplinary laboratory with seven Nobel Prize-winning discoveries, 37 R&D 100 Awards, and more than 70 years of pioneering research. The Lab is primarily supported by the U.S. Department of Energy’s (DOE) Office of Science. Brookhaven Science Associates (BSA) operates and manages the Laboratory for DOE. BSA is a partnership between Battelle and The Research Foundation for the State University of New York on behalf of Stony Brook University.

Organizational Overview

Brookhaven National Laboratory is entering an exciting new chapter with one of the newest and most advanced synchrotron facilities in the world. National Synchrotron Light Source II (NSLS-II) enables the study of material properties and functions with nanoscale resolution and exquisite sensitivity by providing world-leading capabilities for X-ray imaging and high-resolution energy analysis.

This facility is open to users from academia and industry and its operations are at a time when the world enters a new era with a global economy fueled largely by scientific discoveries and technological innovations. NSLS-II provides the research tools needed to foster new discoveries and create breakthroughs in critical areas such as energy security, environment, and human health.

Position Description

NSLS-II has an opening for a post-doc to participate in multi-disciplinary research to help provide a molecular structural view of the mechanisms nitrogenase-like enzymes. Collaborators at the Ohio State University have identified a previously uncharacterized enzymatic system that uses a nitrogenase-like reductase that is distinct from known nitrogenases and nitrogenase-like reductases. The work is supported by the DNA Synthesis Science program at the DOE Joint Genome Institute. Working in a multi-disciplinary, multi-national, team the candidate will carry out research using a macromolecular crystallography, solution scattering and cryogenic electron microscopy. This work will help establish a broader understanding of the molecular structures involved in electron delivery and catalytic reduction in this enzyme class.

Essential Duties and Responsibilities:

  • Protein production and purification.
  • Preparation of samples for experiments.
  • Perform experiments using beamlines and cryo-EM.
  • Analyze data using existing tools and help develop new tools.
  • Publish results.
  • Communication of results to researchers in the community.

Position Requirements

Required Knowledge, Skills, and Abilities:

  • Ph.D. in molecular biology or a related field.
  • Molecular structural determination using crystallography or cryo-EM.
  • Manuscript writing and demonstrated track record of publication.
  • Demonstrated ability to work in a diverse team environment

Preferred Knowledge, Skills, and Abilities:

  • Experience with solution scattering.
  • Experience with handling anerobic enzymes including sample manipulation in an anerobic environment.


 BNL policy requires that research associate appointments be made to individuals who have received their doctorate within the past five years.

At Brookhaven National Laboratory we believe that a comprehensive employee benefits program is an important and meaningful part of the compensation employees receive. Our benefits program includes, but is not limited to:

  • Medical, Dental, and Vision Care Plans
  • Flexible Spending Accounts
  • Paid Time-off and Leave Programs (vacation, holidays, sick leave, paid parental leave)
  • Lab-funded Retirement Plan
  • 401(k) Plan
  • Flexible Work Arrangements
  • Tuition Assistance, Training and Professional Development Programs
  • Employee Fitness/Wellness & Recreation:  Gym/Basketball Courts, Weight Room, Fitness Classes, Indoor Pool, Tennis Courts, Sports Clubs/Activities (Basketball, Ping Pong, Softball, Tennis)

Brookhaven National Laboratory and the Energy and Photon Sciences Directorate are committed to your success. We offer a supportive work environment and the resources necessary for you to succeed.

Brookhaven National Laboratory (BNL) is an equal opportunity employer that values inclusion and diversity at our Lab.We are committed to ensuring that all qualified applicants receive consideration for employment and will not be discriminated against on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, age, status as a veteran, disability or any other federal, state or local protected class.

BNL takes affirmative action in support of its policy and to advance in employment individuals who are minorities, women, protected veterans, and individuals with disabilities.We ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment.Please contact us to request accommodation.

*VEVRAA Federal Contractor

Brookhaven employees are subject to restrictions related to participation in Foreign Government Talent Recruitment Programs, as defined and detailed in United States Department of Energy Order 486.1A. You will be asked to disclose any such participation at the time of hire for review by Brookhaven. The full text of the Order may be found at:

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